Stem cells are now the main focus of the breakthrough of research interest because of their excellent competence to proliferate, regenerate, and differentiate various tissues, giving an enticing chance of growing replacement organs in vitro, one of the possible therapeutic significance.
Cancer is one of the leading causes of mortality in both developed and developing countries. It is also an emerging medical burden globally due to increasing population and aging. Therefore, studies are being worked to develop new and effective therapies with no or low toxicity in normal cells. A stem cell transplant may be needed if you have leukemia or lymphoma. Stem cells help replace damaged cells caused by cancer. It can also help your body recover quickly from chemotherapy and other radiation treatment.
Stem cells for cancer may contribute to most biological hallmarks that vary from their normal-tissue correspondent and that these might be advantageous for therapeutic purposes. Here we elaborate on the significant benefits for Cancer in Thailand and the development of new strategies for cancer with stem cells.
Defining Stem Cells
Stem Cells grow in the inside of your marrow. The marrow is the soft tissue of your bones. You can also find it in your blood and your umbilical cords. Once the stem cells mature, the blood stem cells transform into these three types of cells which your body needs; Platelets, red blood cells, and white blood cells.
Stem cells can develop into all the various bodily tissues at the very beginning of life. On the other hand, cancer cells often end life. Researchers have investigated that the same mechanism might work in both cancer and stem cells with these apparent differences. For example, both can multiply infinitely. It is suspected that the stem cell for cancer functions in a similar process to sustain the growth and spread of tumors while propagating the significant cell types definitely within the tumor.
According to basic cancer research, there is transpiring evidence that stem cell biology provides a breakthrough into cancer biology. Specifically, three factors of the relationship between stem cells and tumor cells are the most critical. First, their similarities in the way they regulate the self-renewal of normal stem cells and cancer cells; second, the greater chance that tumor cells might emerge from normal stem cells; and third, the suspicion that tumors contain “cancer stem cells.”
How Stem Cell Transplants Help Beat Cancer
Stem cell transplant helps recover your capacity to generate stem cells with very high radiation therapy doses and chemotherapy. Although stem cell transplant does not have a direct effect against cancer, multiple myeloma and some types of leukemia may have a direct effect against cancer. This procedure transpires due to the effect called graft-versus-tumor that happens after the allogeneic transplant. Graft-versus-tumor happens when your donor’s white blood cells invade any remaining cancer cells in your body after administered with high-dose treatment. This treatment is known to have a positive effect on a cancer patient.
Probable Therapies Using Stem Cells
Adult Stem Cell Therapy
Adult stem cells are similar to cells in the body that divide to replenish and regenerate damaged tissues. The use of adult stem cells does not need to destroy an embryo, unlike embryonic stem cells. Embryonic stem cells can separate into more than one cell type. Adult stem therapy needs a stem cell origin of the exact lineage required and harvesting and nurturing them up to multiply.
Adult stem cell therapies have been used to treat leukemia and other blood/bone related cancers through bone marrow transplants.
Embryonic Stem Cell Therapy
There is a greater probability to treat Cancer with Embryonic Stem Cell therapy. Embryonic stem cells are derived from similar inner mass cells of a human embryo, which can grow and break down into all derivatives of the three germ layers such as the ectoderm, endoderm, and mesoderm as primary layers. Embryonic stem cell therapy has been discovered to have a potential treatment for tissue replacement after a disease or injury.
Induced Pluripotent Stem Cell Therapies
Induced Pluripotent Stem Cells are significant for research as they provide an endless supply of similar cells to the patients. iPSC or Induced Pluripotent Stem Cells are copied from skin or blood cells reprogrammed similar to an embryonic-like pluripotent state than allows the development of an endless source of any human cell type required for therapeutic purposes.
There are several discoveries on connections between stem cells and cancer that are significant and critical to understanding. Emerging stem cell biology studies extend insight into cancer origin and have ultimately yielded a new approach to beat cancer.
Current research lines and the identification of new therapeutic therapies can be expounded to eliminate cancer stem cells from patients. With most tumors that may exist, cancer stem cells that can self-renew, characterizing, analyzing, and identifying cancer stem cells can have a significant leap in the cure of cancer.